Testicular toxicity evaluation of two antimony compounds, antimony trioxide and antimony potassium tartrate, in rats and mice

Antimony Toxicity

Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. In addition antimony trioxide is possibly carcinogenic to humans. Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. As a th...

The Treatment of Rhinosporidium by Antimony Tartrate

Urinary schistosomiasis treated with sodium antimony tartrate--a quantitative evaluation.

Seventeen Egyptian male farm-workers aged 8 to 27 years infected with Schistosoma haematobium were given twice-weekly intravenous injections of sodium antimony tartrate in a dose of 0.5 g. (30 mg.) per 15 kg. body weight for 12 injections. Bell's egg-count technique was used to evaluate results on 24-hour urine collections before and at 1, 4, 8, and 12 weeks after treatment. Patients were consi...

Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells.

Cross-resistance between cisplatin (DDP) and metalloid salts in human cells was sought on the basis that mechanisms that mediate metalloid salt cross-resistance in prokaryotes are evolutionarily conserved. Two ovarian and two head and neck carcinoma cell lines selected for DDP resistance were found to be cross-resistant to antimony potassium tartrate, which contains trivalent antimony. The DDP-...

Complexation effect of antimony compounds with citric acid and its application to the speciation of antimony(III) and antimony(V) using HPLC-ICP-MS

In this work, a complexation effect of Sb compounds with citric acid was observed using electrospray mass spectrometry (ES-MS). It was found that both Sb(III) and Sb(V) could form complexes readily with citric acid in an aqueous solution at room temperature. These complexes were found to be very stable in various matrices (moat water and aqueous extracts of airborne particulate matter), therefo...